Pharmacokinetic Interaction between Telaprevir and Methadone

Pharmacokinetic interaction between telaprevir and methadone.

Hepatitis C virus (HCV) antibody is present in most patients enrolled in methadone maintenance programs. Therefore, interactions between the HCV protease inhibitor telaprevir and methadone were investigated. The pharmacokinetics of R- and S-methadone were measured after administration of methadone alone and after 7 days of telaprevir (750 mg every 8 h [q8h]) coadministration in HCV-negative sub...

Pharmacokinetic Interaction Between Telaprevir and 1 Methadone 2 3

Potential P-glycoprotein pharmacokinetic interaction of telaprevir with morphine or methadone.

Telaprevir (TVR) effects on P-glycloprotein and cytochrome P450 (CYP) may significantly elevate serum levels of morphine and methadone. Recent literature points to major interactions when combining TVR with warfarin or rifampin. Opioid interactions are especially dangerous in hepatitis C patients, as coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) occurs in 50-90...

Pharmacokinetic Interaction between Pyronaridine-Artesunate and Metoprolol

The objectives of this study were to characterize any drug-drug interaction between the antimalarial Pyramax (pyronaridine-artesunate [PA]) and the CYP2D6 probe substrate metoprolol and to assess the safety of 60-day or 90-day PA redosing, particularly with regard to liver biochemistry parameters. Healthy adult subjects were randomized to arm A (n = 26) or arm B (n = 30), with the arm A subject...

Pharmacokinetic interaction between valproic acid and ertapenem.

An 80-year-old woman with a weight of 74 kg had been primarily diagnosed with complex partial seizures secondary to severe cerebrovascular disease; she also had atrial fibrillation, peripheral artery disease, untreated high blood pressure, and advanced cognitive impairment – she only utters isolated words with a tendency to echolalia. She had an acute thromboembolic stroke two years ago, which ...